e team also showed that cells from human patients with a developmental disorder caused by mutations in MOF also exhibited respiratory defects that could be ameliorated by interventions such as acetylation-mimetic COX17 or mitochondrially targeted MOF.The intricate control of cellular metabolism relies on the coordinated and harmonious interplay between the nucleus and mitochondria.
In previous studies, Asifa Akhtar's lab was able to detect MOF and several of its protein partners in mitochondria. However, the precise impact of MOF's enzymatic activity on mitochondrial function and cellular metabolism remained unknown.
Scientists have identified a protein in fruit flies that can be targeted to reverse the effects of disease-causing mutations in mitochondrial genes. The discovery could provide clues about how to ...
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