The gut microbiome, which is primarily modulated by diet,"has been shown to be a major determinant of circulating
Large-scale genetic studies"have shown that the contribution of genetics to depression is modest," she continued. On the other hand, initial animal studies suggest the gut microbiome"may potentially have a causal influence on depression." Logistic regression analysis was used to test the association of metabolite levels with depression in four models, each with an increasing number of covariates.
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