]. These results suggest that the CAR-T-cell engineering technique with mitochondrial modulation may be a promising therapeutic modality for cancer immunotherapy.Mitochondria are critical cellular organelles and are responsible for many physiological processes, including cellular metabolism, ROS production, and cell death. Mitochondrial dysfunction has been suggested to contribute to various human diseases, including neurodegenerative diseases and cancer.
The cancer-specific differences in mitochondrial alterations, mitochondrial retrograde signaling pathways, and the response to immunotherapy need further investigation to develop precise and personalized medicine against cancer.Mitochondrial alterations and mitochondrial retrograde signaling in cancer progression. Several mitochondrial alterations have been implicated in various types of human cancers.