Though more research is needed, the researchers said the study shows that these disrupted rhythms can be seen in as little as three days, which suggests early intervention to prevent diabetes and obesity is possible. Such intervention could also help lower the risk of heart disease and stroke, which is elevated in night shift workers as well.
"There are processes tied to the master biological clock in our brain that are saying that day is day and night is night and other processes that follow rhythms set elsewhere in the body that say night is day and day is night," said senior study author Hans Van Dongen, a professor in the WSU Elson S. Floyd College of Medicine."When internal rhythms are dysregulated, you have this enduring stress in your system that we believe has long-term health consequences.
However, most other proteins had rhythms that changed substantially in night shift participants compared to the day shift participants. The researchers' next step will be to study real-world workers to determine whether night shifts cause similar protein changes in long-term shift workers.Jason E. McDermott, Jon M. Jacobs, Nathaniel J. Merrill, Hugh D. Mitchell, Osama A. Arshad, Ryan McClure, Justin Teeguarden, Rajendra P. Gajula, Kenneth I. Porter, Brieann C. Satterfield, Kirsie R. Lundholm, Debra J. Skene, Shobhan Gaddameedhi, Hans P. A. Van Dongen.
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