Analysis revealed significantly lower levels of extracellular acidification and oxygen consumption in the white blood cells of veterans with GWI.A new Duke University-led study finds that Gulf War Illness , which affects approximately 250,000 U.S. veterans, significantly reduces their white blood cells' ability to make energy and creates a measurable biochemical difference in veterans who have the disease.
"Knowing this is an energetic deficiency can help us zero in on more effective ways to relieve the symptoms," Meyer said."Blood tests, repeated over the course of the treatment, would show if a veteran's white blood cells are responding to a treatment and producing more energy." The analyses revealed no evidence of DNA damage, but they did show significantly lower levels of extracellular acidification and oxygen consumption in the white blood cells from veterans with GWI -- signs that their mitochondria were generating less energy.Follow-up blood tests on about a third of the veterans showed that some of these levels could vary over time, but the general pattern remained: the cells of veterans with GWI produced less energy.
Coauthors on the new paper were William Pan and Ian Ryde of Duke; Thomas Alexander, Jacquelyn Klein-Adams and Duncan Ndirangu of the U.S. Department of Veteran Affairs' War-Related Illness and Injury Study Center ; and Michael Falvo of WRIISC and the New Jersey Medical School at Rutgers Biomedical and Health Science.Joel N. Meyer, William K. Pan, Ian T. Ryde, Thomas Alexander, Jacquelyn C. Klein-Adams, Duncan S. Ndirangu, Michael J. Falvo.
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