To date, it is unclear whether the use of MCTs might increase the acute ketogenic response. Nevertheless, a 30 day clinical trial reported that the consumption of caprylic acid increased plasma β-hydroxybutyrate concentration from ~ 0.1 mmol/L to ~ 0.2 mmol/L [To the best of our knowledge, no previous studies investigated the potential effects of MCTs supplementation during VLCKD for a greater reduction of body weight and fat mass in individuals with overweight and obesity.
Against this background, the present study aimed to evaluate whether the supplementation with MCTs can induce a greater weight reduction during the ketogenic phase of VLCKD. For this purpose, we retrospectively investigated the effect of MCTs supplementation in addition to dietdiet alone in a group of individuals with overweight/obesity undergoing a VLCKD.
of the Federico II University Hospital were retrospectively collected between September 2021 and September 2022. All participants provided written consent after being informed about the study design. The study has been approved by the Local Ethical Committee . The present analyses included a total of two time points: at baseline and during the VLCKD active stage after 45 days with the collection of anthropometric measures and body composition.
]. Individuals eligible for this study presented the following features: women aged 18–69 years, body mass index 25.0–50.9 kg/mat the beginning of the nutritional treatments.