By Tarun Sai LomteApr 22 2024Reviewed by Benedette Cuffari, M.Sc. A recent study published in the journal Nature Aging reports that small extracellular vesicles in plasma from young mice counteract preexisting aging.
About the study EVs are nano-sized membranous vesicles that circulate throughout the bloodstream and serve as intercellular messengers by exchanging cargoes between cells. In the current study, researchers explored the rejuvenating effects of sEVs. Mating with young males resulted in 7.7 implantation sites/pregnant females, whereas aged mice failed to establish implantation sites. Nevertheless, treatment of aged mice with young sEVs significantly improved fertility defects, with 3.4 sites/pregnant female.
Aged mice exhibited increased senescence-associated β-galactosidase activity in the spleen, kidney, liver, lung, testis, and hippocampus compared to young mice. However, treating aged mice with young sEVs, even for two weeks, led to a rapid reduction in SA-β-gal levels in these organs.