Metabolic activity makes the brain especially vulnerable to oxidative damage.Your brain is a metabolically fierce organ, punching way above its weight of two pounds to consume 20 to 25 percent of the body’s fuel supply. The brain’s energy-making machinery, centered in mitochondria, is powering your ability to see this page, decode the symbols, take in the information, and maybe even store some of it in.
As the descendants of once-independent organisms, mitochondria retain some autonomy; for example, they have their own DNA, something that helps mitochondria respond quickly to local energy demands without having to first consult the nuclear DNA. It also allows mitochondria to multiply on their own. Mitochondrial dysfunction from any cause not only leads to a decrease in ATP levels and energy production and an increase in the generation of ROS but it can also lead to inflammation. If, because of reduced mitochondrial function, defective mitochondria are not removed by mitophagy, they can release their contents, setting off inflammatory processes.
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Fonte: physorg_com - 🏆 388. / 55 Consulte Mais informação »